Why should I change from using a total light chain measurement to a more expensive free light chain assay?
Normal serum FLC concentrations are 10-30mg/L, which is much lower than total light chain concentrations of 1,000-3,000 mg/L. Patients who have levels of FLC above 30mg/L and below the normal range of total light chains can be diagnosed and monitored with Freelite assays but not total light chain assays. Since this applies to most patients with AL amyloidosis, nonsecretory myeloma and many light chain myelomas, Freelite assays have considerable clinical application in these diseases.
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