Where can a company find guidance for the tests included in the HPV Challenge Program?
General guidance on participation can be found in the “Principles for Participation in the High Production Volume Challenge Program,” available from EPA through its TSCA Hotline at 202-554-1404, or through the web site at http://www.epa.gov/opptintr/chemrtk/pubs/general/guidance.htm. The baseline hazard information has been defined by the Organization for Economic Cooperation and Development (OECD) in its Screening Information Data Set (SIDS). SIDS represents an internationally agreed upon set of tests to screen chemicals and identify potential hazards. The basic screening endpoints to be tested are: acute toxicity, chronic toxicity, developmental and reproductive toxicity, mutagenicity, ecotoxicity, environmental fate, and physical-chemical properties, and are listed in Section 2.2 (page 2) of “Screening Information Data Set Manual of the OECD Programme on the Co-operative Investigation of High Production Volume Chemicals,” published in July, 1997. This manual (also called the “SIDS M
