What is the correct dose to use for LDN?
Since LDN works through a “rebound effect” (for details please see the explanatory section “How Does Low Dose Naltrexone Work?”, its beneficial effects only begin taking place once the LDN has been metabolized and removed from the cells. Since metabolism varies between individuals, there is no single dose that will work for every person. Some people find that a daily dose as low as 2mg is effective, and others have found that they achieve greatest benefit using two doses of 4.5mg each day (12 hours apart). The clinical trials so far have used a single daily dose of 4.5mg and for most users this dose seems to be effective.
