What is Natalizumab?
Natalizumab is a monoclonal antibody that binds to a protein called alpha-4-integrin. Integrins are found primarily on the surface of white blood cells, and play a role in immune system activity. 2. What are monoclonal antibodies? Antibodies are naturally occurring proteins produced by the immune system in response to foreign substances. Once produced by the body, they recognize and bind to specific proteins (antigens) on bacteria, viruses, and toxins, to help the body fight disease. Monoclonal antibodies, such as natalizumab, are produced in cell culture systems. They can be designed to bind to receptors on the body’s normal cells. By recognizing and attaching to these receptors, monoclonal antibodies can interfere with (or alter) normal or abnormal cellular responses. In this way, monoclonal antibodies may be useful in the treatment of certain diseases. 3. What is natalizumab used to treat? Natalizumab is approved to treat patients with relapsing forms of multiple sclerosis to reduce
