What is a pagination guide?
It’s a mock-up of the way you expect the finished comic to look, with the pages placed in the order and orientation that you expect. This is especially important if your book design includes upside-down or sideways pages, like in a flipbook. Typically, you double-sided copy the pages that are supposed to go together. I generally make a couple extra when I do it, so I have mock-ups to show people while I’m waiting for the book to come back from the printer. I did quite a few books without doing this, but when we did flip-books, it was an absolute must.