What Drug Interactions Are Relevant to Emergency Contraceptive Use?
• Women using liver enzyme-inducing drugs should be advised that an IUD is the preferred option for EC (Grade A). • Women who are using liver enzyme-inducing drugs who are given 0.75 mg tablets of LNG (Levonelle-2) should be advised to take a total of 2.25 mg (three tablets) as a single dose, as soon as possible and within 72 hours of UPSI. This use is outside the product licence (Grade C). • Women who are using liver enzyme-inducing drugs who are given 1.5 mg tablets of LNG (Levonelle One Step or Levonelle 1500) should be advised to take a total of 3 mg (two tablets) as a single dose, as soon as possible and within the 72 hours of UPSI. This use is outside the product licence (Good Practice Point). • Women using non-liver enzyme-inducing antibiotics (short- or long-term) should follow the normal LNG regimen (1.5 mg within 72 hours of UPSI) (Grade C). • There are no drugs that are known to affect emergency IUD use (Grade C). What Clinical Examinations and Investigations Are Required Be
