What criteria should the IACUC consider when reviewing protocols?
• the protocol is consistent with the Guide unless a scientific justification for a departure is presented and is acceptable to the IACUC; • the protocol conforms with the institution’s Assurance; • the protocol will be conducted in accordance with the USDA Animal Welfare Regulations if applicable; and • the protocol meets the requirements of the PHS Policy at IV.C.1.a.-g. For further guidance, the IACUC should refer to the U.S. Government Principles.
• the protocol is consistent with the Guide unless a scientific justification for a departure is presented and is acceptable to the IACUC; • the protocol conforms with the institution’s Assurance; • the protocol will be conducted in accordance with the USDA Animal Welfare Regulations if applicable; and • the protocol meets the requirements of the PHS Policy at IV.C.1.a.-g. For further guidance, the IACUC should refer to the U.S. Government Principles. • Should the IACUC consider the three “Rs” of alternatives when reviewing protocols? (Refinements to research, Reduction of animal numbers, and Replacement with non-animal models) The federal mandate in U.S. Government Principle IV to avoid or minimize discomfort, distress, and pain in experimental animals consistent with sound scientific practices, is synonymous with a requirement to implement refinements (e.g., less invasive procedures or use of analgesia). Similarly, the mandate in U.S. Government Principle III to use the minimum numbe
