What are SNPs?
Single nucleotide polymorphisms, or SNPs (pronounced “snips”), are DNA sequence variations that occur when a single nucleotide (A,T,C,or G) in the genome sequence is altered. For example a SNP might change the DNA sequence AAGGCTAA to ATGGCTAA. For a variation to be considered a SNP, it must occur in at least 1% of the population. SNPs, which make up about 90% of all human genetic variation, occur every 100 to 300 bases along the 3-billion-base human genome. Two of every three SNPs involve the replacement of cytosine (C) with thymine (T). SNPs can occur in coding (gene) and noncoding regions of the genome. Many SNPs have no effect on cell function, but scientists believe others could predispose people to disease or influence their response to a drug.
SNP (pronounced “snip”) stands for single nucleotide polymorphism. A single nucleotide nolymorphism is defined as a single DNA base substitution that is observed with a frequency of at least 1% in a given population. Millions of SNPs have been cataloged in the human genome including some that are responsible for disease as well as others that are normal variations.
Single nucleotide polymorphisms, or SNPs (pronounced “snips”), are DNA sequence variations that occur when a single nucleotide (A,T,C,or G) in the genome sequence is altered. For example a SNP might change the DNA sequence AAGGCTAA to ATGGCTAA. For a variation to be considered a SNP, it must occur in at least 1% of the population. SNPs, which make up about 90% of all human genetic variation, occur every 100 to 300 bases along the 3-billion-base human genome. Two of every three SNPs involve the replacement of cytosine (C) with thymine (T). SNPs can occur in coding (gene) and noncoding regions of the genome. Many SNPs have no effect on cell function, but scientists believe others could predispose people to disease or influence their response to a drug. Although more than 99% of human DNA sequences are the same, variations in DNA sequence can have a major impact on how humans respond to disease; environmental factors such as bacteria, viruses, toxins, and chemicals; and drugs and other th
Related Questions
- Every time I search for STS markers in dbSNP, dbSNP returns a screen that says that no SNPs were found in my region of interest. What am I doing wrong?
- How I match SNP names from the Seattle SNPs database (e.g. a Seattle SNPs named UI1498 in the IL10 gene) to dbSNP rs numbers in dbSNP?
- How many SNPs can be included in an iSelect Infinium Custom Genotyping project?
