How safe is natural progesterone cream?
During the third trimester of pregnancy, the placenta produces about 300 mg of progesterone daily, so we know that a one-time overdose of the cream is virtually impossible. If you used a whole jar at once it might make you sleepy. However, Dr. Lee recommends that women avoid using doses higher than are recommended to avoid hormone imbalances. More is not better when it comes to hormone balance.