How is GrailEXP used?
GrailEXP is used at the Computational Biology Section at ORNL to annotate the entire known portion of the human and mouse genomes, including both finished and draft data. GrailEXP is also included in the annotations offered by Celera and DoubleTwist, among others. GrailEXP provides users with many different capabilities. Some use it just to get an idea of where coding is in their favorite sequence. Others are interested in using it as a sim4-like EST alignment program. Some are interested in comparing human genomic sequence with mouse ESTs. Others are more interested in the development of gene-finders for model organisms such as rice, corn, and wheat. Others use the program just to align a single mRNA with a genomic sequence suspected of containing that gene. Finally, some use the program to quickly mask a sequence for repetitives. GrailEXP is used in many different ways, depending upon the needs of its users.
