How high of a dose of doxycycline is needed for adults to allow the medications to be bactericidal instead of bacteriostatic?
The typical doses (100 mg 2 X day) of Doxycycline that were prescribed by many doctors were not high enough to be considered bacteriostatic (killing action) for Lyme disease. To enhance antibiotic action several other agents are now being prescribed along with the antibiotics in order to increase effectiveness. Additionally, the recommendations for Doxycycline doses now range from 300-600 mg a day unless contraindicated. If necessary, Doxycycline can be administered by IV to keep blood levels high or in combination with other antibiotics (such as cyst busters).
