How does Champix work?
Varenicline (trade name Champix – Chantix) mimics the effects of nicotine on the body, and it both reduces the urge to smoke and relieves withdrawal symptoms. The pill interferes with the receptors in the brain that are stimulated by nicotine. By partly stimulating the nicotine receptors it mimics the effects of taking nicotine, and also partially blocks the receptors thereby blunting the effect of nicotine in people who give in to temptation and have a cigarette.
Champix tablets contain the active ingredient varenicline, a type of medicine called a nicotinic acetylcholine receptor partial agonist. This means that it acts on the same receptors in the brain as nicotine does.Varenicline works by stimulating the nicotinic receptors in the brain. This produces an effect that relieves the craving and withdrawal symptoms you can get when you stop smoking. At the same time, varenicline blocks nicotine from acting on the receptors. This reduces the satisfaction a smoker receives when smoking a cigarette.
Champix contains the active ingredient Varenicline that works by binding to alfa4-beta2 nicotinic acetylcholine receptors of neurons acting as a partial agonist – a compound that has both agonist activity, but in the presence of nicotine exerts an antagonistic effect.Electrophysiological studies conducted in vitro and in vivo have shown that varenicline binds to alfa4-beta2 neuronal nicotinic acetylcholine receptors and stimulates receptor-mediated activity at a much lower level than nicotine. Varenicline effectively blocks the ability of nicotine to fully activate alfa4 beta2-receptors and mesolimbic dopamine system. As a result smoking does not bring pleasure and some cases even cause negative feeling. Varenicline prevents and relieves the symptoms of withdrawal syndrome. According to the study Chantix helps to quit smoking in more than 44% of patients that finished 12-week course of treatment. Which is Champix pharmacokinetics? The maximum concentration of varenicline in plasma usua
This is certain that everyone who will take up smoking will soon become an addict to nicotine – chemical substance in cigarettes. Nicotine travels into your nerve system where in connection with receptors it frees dopamine, which is responsible for the pleasant feeling when you are smoking. The active substance in Champix, verenicline, is binding with some of the receptors and is working in two ways: it acts as nicotine, which allows decreasing nicotine hunger as well as is working in opposite way, replacing nicotine which helps to decrease the pleasant feeling of the smoking habit.
Champix tablets contain the active ingredient varenicline, a type of medicine called a nicotinic acetylcholine receptor partial agonist. This means that it acts on the same receptors in the brain as nicotine does. Varenicline works by stimulating the nicotinic receptors in the brain. This produces an effect that relieves the craving and withdrawal symptoms you can get when you stop smoking. At the same time, varenicline blocks nicotine from acting on the receptors. This reduces the satisfaction a smoker receives when smoking a cigarette.
