How do I determine the position, in numbers, of the mutations on my MatriLine certificate?
• Your mitochondrial DNA (mtDNA) sequence is shown at the bottom of your certificate. This sequence is the section of mtDNA between positions 16001 and 16400 base pairs on the mitochondrial chromosome, which we analyse for our MatriLine service. Any changes (mutations) from the Cambridge Reference Sequence (CRS) are shown in red. More details about the CRS may be found HERE If you count across from position 16001at the start of the sequence on your certificate, to the point where there are any letters highlighted in red, then this will give you the position, as a number, of each mutation. So, for example, if there is a red T (thymine) 23 base pairs in, on the third row of the sequence, then this is at position 16223, each of the four rows being 100 base pairs long. At the corresponding position on the CRS, there is a letter C (cytosine), and so this particular mutation may be written as 16223 C-T, as the C present in the CRS has changed to a T. Mutations can be written in an abbreviate
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