How can GastroPlus help me with formulation design?
The Parameter Sensitivity Analysis feature allows you to quickly examine the effects of formulation parameters (e.g., particle size, particle shape) on the absorption or PK/PD response. With the optional Optimization module, you can determine the optimum in vivo release profile to achieve the desired plasma concentration-time profile or to keep steady-state plasma concentration within a therapeutic window. The new IVIVCPlus module allows you to quickly and easily establish an in vitro-in vivo correlation (IVIVC). This refers to finding the relationship between how a dosage form dissolves in the lab (in vitro) with how it dissolves in human or animals (in vivo). The understanding of these differences helps scientists in several ways: (1) designing the ideal formulation faster and with fewer experiments, (2) designing an in vitro experiment that is a better representation of in vivo release, and (3) getting better estimates of blood concentration-time profiles for similar new formulation
