enriched with disease-related proteins?
Yes. • The set of 60 human multi-pathway proteins is enriched with disease-related proteins (listed in OMIM or GAD): 43% (26) of them are known to be disease-related, while in the 8 human signaling pathways only 25.5% (165 of 646) and among all human proteins listed by Ensembl only 20% (3 929 of 19 534). • Of the 121 human predicted signaling pathway member proteins 27 (22%) are known to be disease-related, which is smaller than the 30% (192 of 646) in all 8 pathways, but higher than the 20% (3 929 of 19 534) among all human proteins.
