Can Vetsulin be diluted?
No. Vetsulin is a mixture of amorphous (soluble) insulin and crystalline insulin. The crystalline part is relatively insoluble which is why the insulin activity lasts more than a few hours. Vetsulin has a balance between the amorphous and crystalline parts. If Vetsulin is diluted, the balance between amorphous and crystalline parts is no longer 30% and 70%, relatively speaking. The amount of soluble insulin is increased by the aqueous diluent used. This results in an alteration of the pharmacokinetics of Vetsulin. With a larger aqueous fraction and smaller crystalline fraction, there would be a decrease in the crystalline portion responsible for the second peak of insulin activity.
