You say that the sulfurizing reagent, 40-4036, is stable for 1 month in solution “under ideal conditions”. What are ideal conditions?
RESPONSE:The sulfurizing reagent, developed by Beaucage, is a very reactive product. In solution in acetonitrile, it must be stored in plastic or silanized glass containers. Solutions in sealed bottles are stable for periods of months, turning cloudy and finally precipitating as decomposition occurs. On most synthesizers, the sulfurizing reagent must be installed on the port previously used for the iodine oxidizing solution. In this situation, the reagent will decompose quite rapidly over 24 to 48 hours. Indeed, we recommend weighing out the required amount of dry reagent into the silanized bottle provided. The recommended concentration for use is 1g/100mL So, if 40mL of solution is desired, weigh 0.4g of reagent into the silanized bottle and add 40mL of acetonitrile. It is important to flush the synthesizer line liberally first with acetonitrile then with the sulfurizing solution to remove traces of the previous solution from the line. After synthesis, we recommend removing the soluti
