Would suicide gene therapy solve the ‘T-cell dilemma’ of allogeneic bone marrow transplantation?
The mature T cells that acccompany hematopoietic stem cells during allogeneic bone marrow transplantation can mediate both beneficial and deleterious clinical effects. Suicide genes that metabolize inactive prodrugs into compounds highly toxic for dividing cells, should enable elimination of genetically modified activated T cells when necessary by time-controlled prodrug administration.
