Would it be safe to breed one female gerbil in a tank with three of her sisters?
Is there a reason you are breeding them? Breeders that go into breeding do so for the betterment of the entire species, not for profit or fun. Actually, many breeders lose money by breeding as it costs quite a bit to raise the young and socialize them. You need to take into account the fact that they all may end up with respiratory issues that need antibiotics and vet visits. A good breeder will have all the babies checked by a vet prior to adopting them out (which is quite pricey) and they have their potential adopters fill out extensive applications. These same good breeders only breed when they have a list of adopters that have been researched and found to be perfect matches for the babies. They also have gerbils that they breed from that are several generations down and can tell you their parents/grandparents/great-grandparents, etc. and can tell you the health and history of each gerbil from the line. Breeders use gerbils that are bred from other gerbils that have good health hist