Would blood test results indicate Fatty Liver?
Hi,Kitten Fatty change represents the intra-cytoplasmic accumulation of triglyceride (neutral fats). At the beginning, the hepatocytes present small fat vacuoles (liposomes) around the nucleus – microvesicular fatty change. In this stage liver cells are filled with multiple fat droplets that do not displace centrally located nucleus. In the late stages, the size of the vacuoles increases pushing the nucleus to the periphery of the cell giving characteristic signet ring appearance – macrovesicular fatty change. These vesicles are well delineated and optically “empty” because fats dissolve during tissue processing. Large vacuoles may coalesce, producing fatty cysts – which are irreversible lesions. Macrovesicular steatosis is the most common form and is typically associated with alcohol, diabetes, obesity and corticosteroids. Acute fatty liver of pregnancy and Reye’s syndrome are examples of severe liver disease caused by microvesicular fatty change.
