With the FDA imposed reduction in dietary selenium levels, should I increase dietary vitamin E since they are both antioxidants?
A. Even though they are both antioxidants, they have different sites of action. Vitamin E acts on the biomembranes while selenium-dependent glutathione peroxidase acts in the cytoplasm. Vitamin E tends to be most effective in preventing lipid peroxidation while selenium is more effective in preventing free radical production. The benefits of increasing vitamin E are doubtful if you are feeding the maximum allowable level of selenium.
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