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With such low intravenous doses, how can you be sure that the method for measuring the drug concentration in plasma is sufficiently sensitive?

April 26, 2017concentration doses drug Intravenous low measuring method Plasma sufficiently sure

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With such low intravenous doses, how can you be sure that the method for measuring the drug concentration in plasma is sufficiently sensitive?

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Accelerator Mass Spectrometry (AMS) is the most sensitive analytical method there is. If 200 nCi, 1ug of 14C-drug is administered, then the assay sensitivity will be around 1 fg/mL plasma.