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With Prazosin and Terazosin, how come there is no reflex tachycardiac?

April 26, 2017prazosin Reflex terazosin

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With Prazosin and Terazosin, how come there is no reflex tachycardiac?

1 Answer

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10 Posted

Phentolamine (non-selective, alpha1- and alpha2-blocker) causes a fall in BP with refex tachycardia. Whereas Prazosin and Terazosin are selective alpha1-blockers. It is thought that since they leave the presynaptic alpha2-receptors operational, this prevents the reflex tachycardia.