Will the Tonal Plexus retune software instruments like Garritan Orchestra?
Yes. Depending on how you are working with the samples, you can use either the tuned output from the keyboard (OUT) which requires an instrument per voice (channel) of the selected polyphony, or you can use the untuned output (THRU) to send raw MIDI note messages if your sample playback software already has its own microtonal key mapping support. Garritan is a good choice for microtuning because it supports scala .scl files, so you can play microtunings with increased polyphony, but going that route requires you to set up tuning tables in Garritan, which has limitations and does not allow changing tunings on the fly, which is nowhere near as flexibile as using the tuned output from TPX.