Will the level of leucodepletion prevent my patient getting febrile non-haemolytic (FNH) reactions?
Prestorage leucodepletion has been shown to reduce FNH transfusion reactions. The two main mechanisms thought to cause FNH reactions include cytokine release by contaminant white cells into stored blood components and recipient antibodies reacting with foreign donor white blood cell antigens. Leucodepletion of blood components within 24 hours of collection results in a reduction in the white blood cells present to react with recipient antibody and a reduction in cytokine release into the blood component, thereby ameliorating the two main mechanisms of FNH reactions. As one of the benefits of pre-storage leucodepleted blood components is a reduction in FNH transfusion reactions, fevers associated with the transfusion of such a component should be carefully assessed to exclude complications such as bacterial contamination.
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- Will the level of leucodepletion prevent my patient getting febrile non-haemolytic (FNH) reactions?
