Will the Lessons From Primary Aldosteronism Change the Treatment of Hypertension and Left Ventricular Hypertrophy?
From the Divisions of Endocrinology and Metabolism (R.J.A.) and Cardiology (M.H.D.), Department of Internal Medicine, and the Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas. Correspondence to Richard J. Auchus, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8857. E-mail Richard.auchus{at}utsouthwestern.edu’ + u + ‘@’ + d + ”//–> The renin-angiotensin-aldosterone system effectively defends against volume depletion, but in most developed nations, dietary sodium is high, and aldosterone production should be suppressed. The syndrome of primary aldosteronism demonstrates the consequences of autonomous aldosterone production in a sodium-replete society. For many years, primary aldosteronism was thought to be an esoteric disorder only diagnosed by academicians at a handful of institutions worldwide. Conn, Bi
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