Will pyruvate be an effective supplement to take during the dieting phase of the ABCDE Program?
I believe the chief benefit of using pyruvate during dieting may be as an energy substrate in the liver cells, which need energy to convert inactive thyroid (T4) to the active thyroid (T3). Because of the reduction in calories, when you diet you eventually experience a lowered body temperature, which indicates diminished T3 output from the liver. When this happens depends on the amount of carbohydrates in your diet as well as your activity level. Because the dieting phase on the ABCDE Program lasts only two weeks, even in a worst-case scenario (i.e., a no-carb diet and daily aerobics), you would maintain most of your regular T3 output because of existing liver glycogen and gluconeogenesis from glycerol and ala-nine. And the subsequent two weeks of overfeeding (especially with carbs) after the dieting phase is more than enough time to replenish depleted ATP (if it has diminished enough to affect T3 levels). I should remind you that the human trials studying pyruvate for fat loss used a
