Will Prilosec® (or other protein pump inhibitors) affect Vivotif®?
In the lab, it has been shown that the capsules are not affected for up to 2 hours at stomach pH of 3 and 5. The stomach acidity is likely around that pH if people are treated with protein pump inhibitors. The conclusion is that the experiments show that there is no evidence for damage to the capsule at the above stated pH for at least 2 hours. Thus vaccination can take place while being treated with proton pump inhibitors. TO AVOID ANY POTENTIAL DIRECT EFFECT OF THE MEDICATION ON VIVOTIF, IT IS RECOMMENDED TO SPACE INTAKE OF THE TWO MEDICATIONS BY 12 HOURS (ONE IN AM, ONE IN PM) Prilosec® is the registered trademark for Omeprazole.
