Will maternal interference cause problems with use of Nasal Vac in piglets?
No evidence of maternal interference has been uncovered from our research or over many years of field use of this product. Sows naturally infected with Bb or immunized with commercial or autogenous bacterins containing killed Bb will provide piglets colostrum containing specific IgG antibodies to Bb. This passive immunity will provide systemic protection against deep turbinate damage from Bb toxins but these IgG antibodies will not protect the respiratory epithelium surface from infection and colonization by pathogenic Bb, nor will they interfere with our vaccine activity. Predominantly IgA secretory antibody protects the upper airway ciliated mucous layer. Secretory antibodies (mucosal immunity) are generally produced by localized infections of the epithelial surfaces (respiratory or intestinal mucosa) and are not generated in response to systemic vaccination. Plasma cells in the lamina propria immediately below the basement membrane of the surface epithelia produce IgA secretory anti
