Important Notice: Our web hosting provider recently started charging us for additional visits, which was unexpected. In response, we're seeking donations. Depending on the situation, we may explore different monetization options for our Community and Expert Contributors. It's crucial to provide more returns for their expertise and offer more Expert Validated Answers or AI Validated Answers. Learn more about our hosting issue here.

Why X-Scores result is always a small number while some other scoring functions give scores around several hundred?

April 26, 2017functions scores scoring small x-score

0

Posted

Why X-Scores result is always a small number while some other scoring functions give scores around several hundred?

1 Answer

0

Posted

Because the scores are given in different units. X-Score gives dissociate constant of the given protein-ligand complex in negative logarithm units (-logKd). For example, for mili-molar (mM) affinity, -logKd = 3.0; for micro-molar (uM) affinity , -logKd = 6.0; while for nano-molar (nM) affinity, -logKd = 9.0. So, X-Score’s result is usually a positive number under 10.