Why Use Liposomes in Drug Delivery?
: Why Use Liposomes in Drug Delivery? Drug Targeting Inactive: Unmodified liposomes gather in specific tissue reticuloendothelial system Active: alter liposome surface with ligand (antibodies, enzymes, protein A, sugars). Physical: temperature or pH sensitive liposomes Directly to site 07/12/2009 4 SNIOP COLLEGE OF PHARMACY, PUSAD PRESENTED BY- S.R. SHIMBRE Slide 5: Pharmacokinetics – efficacy and toxicity Changes the absorption and biodistribution Deliver drug in desired form Protection Decrease harmful side effects Protects drug 07/12/2009 SNIOP COLLEGE OF PHARMACY, PUSAD PRESENTED BY- S.R. SHIMBRE 5 ADVANTAGES OF LIPOSOMES : ADVANTAGES OF LIPOSOMES Provides selective passive targeting to tumor tissues (liposomal doxorubicin) (in short tissue targetting). Increased efficacy and therapeutic index Reduction in toxicity of the encapsulated agent Site avoidance effect (avoids non-target tissues) Improved pharmacokinetic effects (reduced elimination increased circulation life times) Flexi
