Why use DSC during downstream process development?
• Rapidly, in days compared to weeks, optimize loading and elution conditions throughout purification. • Increase the efficiency and yield of biotherapeutic purification, resulting in substantial financial savings. • Easily determine guidance for optimal in-process storage and handling conditions before making critical decisions. • Easily assess which candidate will be more easily manufactured before further critical development decisions are made. • Guide the selection of chromatographic methods before carrying out purification. Purification processes can also affect biological activity. Various analytical methods are commonly employed to monitor the biological activity of monoclonal antibodies, antibody-like proteins and other biotherapeutics as well as vaccines during the development process to confirm that the molecules remain functionally active throughout development. Isothermal Titration Calorimetry (ITC) provides a rapid and easy way to monitor the biological activity of a biot
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