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Why the success rate of unrelated donor transplants is about 50%?

April 26, 2017donor rate success transplants unrelated

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Why the success rate of unrelated donor transplants is about 50%?

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A8: The success rate of unrelated donor transplants is no more than 50% because of increased risk of rejection of the graft, and increased risk of graft-versus-host disease (GVHD), a complication in which the new marrow reacts against the patient. The severity of GVHD can range from mild to life threatening, and its incidence is higher among older patients and in mismatched transplants.