Why some cancers become malignant and others dont???
Scientists now know why some cancers become malignant and others don’t Published: Thursday, January 6, 2011 – 05:36 in Health & Medicine Cancer cells reproduce by dividing in two, but a molecule known as PML limits how many times this can happen, according to researchers lead by Dr. Gerardo Ferbeyre of the University of Montreal’s Department of Biochemistry. The team proved that malignant cancers have problems with this molecule, meaning that in its absence they can continue to grow and eventually spread to other organs. Importantly, the presence of PML molecules can easily be detected, and could serve to diagnose whether a tumor is malignant or not. “We discovered that benign cancer cells produce the PML molecule and display abundant PML bodies, keeping them in a dormant, senescent state. Malignant cancer cells either don’t make or fail to organize PML bodies, and thus proliferate uncontrollably,” Ferbeyre explained.
