Why Should Nuclear Envelope Proteins Be Dynamic?
Figure 1 Schematic view of the organization of the interphase (more…) Figure 1. Schematic view of the organization of the interphase nuclear envelope (Left) Nuclear membranes can be seen clearly as a subcompartment of the ER studded by nuclear pores and closely apposed to the nuclear lamina and peripheral chromatin. Also shown are the exclusively cytoplasmic microtubules and centrosomes. (Right) The four major structural components of the NE drawn to their approximate molecular scale. The cytoplasm (white) is separated from the nucleoplasm (gray) by the nuclear membranes consisting of outer nuclear membrane (ONM) facing the cytoplasm, pore membrane embedded in the nuclear pore complex (NPC), and inner nuclear membrane (INM) facing the nuclear lamina. Peripheral chromatin is shown schematically as a 30 nm fiber composed of DNA wrapped around nucleosomes. Substructures of the nuclear pore complex shown are the central spoke ring complex (embedded in the membranes), as well as cytoplasm
