Why should Alfaxan® be injected slowly, over 60 seconds?
It takes about 20-30 seconds for Alfaxan® injected into the cephalic vein to reach the brain. If Alfaxan® is injected as a bolus, then less time is available for brain absorption of the alfaxalone needed to induce anaesthesia. A lower total amount of alfaxalone crosses the blood-brain barrier, but higher initial concentrations might be reached in the brain.
