Why screen all 24 chromosomes?
Aneuploidy can affect any chromosome. When only a portion of the chromosomes are evaluated, as with FISH, there is still a chance for aneuploidy of one or more of the untested chromosomes. Studies comparing analysis of nine chromosomes to 24 chromosomes have found that up to 25% of aneuploid embryos would test normal with FISH simply because the other chromosomes were not tested. This means that 1 in 4 blastomeres with a problem would not be detected using FISH. Accurate screening of each embryo across all 24 chromosomes greatly decreases the chance that an aneuploid embryo will be transferred to the mother. As embryos with aneuploidy are prone to miscarriage or often fail to implant at all, this should in theory improve the chance of a successful IVF cycle and pregnancy.
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