Why predict protein structure?
The connection between protein structure [the three-dimensional disposition of chemical functionalities that comprise Nature’s palette of 20 natural amino acids which form the basis for all chemical processing in living organisms] and protein sequence [the one-dimensional expression of the chemical diversity of molecular organization that Nature expresses in individual genes composing the genome] remains as one of the premier challenges to physicists, chemists, biologists and information and computer scientists today. This challenge is particularly critical as a result of our recent advances in the methodologies to elucidate all the genes of entire organisms, including the humane genome, to identify the partnering of these genes in controlling cellular processes, as in cellular networks, and the well-established link between a protein’s three dimensional structure and its biochemical function. Molecular scientists have made significant progress in addressing this challenge through the
