Why not vaccinate the entire population now?
Smallpox vaccine is a live-virus vaccine which contains vaccinia (not smallpox) virus, and which does have severe and life-threatening side effects for some people. CDC estimates that 1 person in 10,000 who receives the vaccine will have serious side effects that require a doctor’s care. Also, if the vaccine were to be given to everyone in the United States, it is estimated that 350 to 500 people would die from the vaccine. That is about 1 or 2 deaths for each million doses of smallpox vaccine administered.
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