Why not to use antimicrobial rinse such as chlorhexidine gluconate within 2 hours of using fluoride toothpaste containing sodium lauryl sulfate?
It is suggested not to use antimicrobial rinses, such as chlorhexidine gluconate (CHA) or cetylpyridinium chloride (CPC) within 2 hours of fluoride toothpaste containing sodium lauryl sulfate because the sodium laurel sulphate saponification component in dentifrice can reduce chlorhexidine activity.. What is Cetylpyridinium Chloride (CPC) CPC is a cationic quaternary ammonium compound in some types of mouthwashes, toothpastes, lozenges, throat sprays, anti-snore throat sprays, breath sprays, and nasal sprays. It is an antiseptic that kills bacteria and other microorganisms. It has been shown to be effective in preventing dental plaque and reducing gingivitis. It has also been used as an ingredient in certain pesticides. This ingredient has also been shown to cause brown stains between the teeth. CPC has a positive cationic (Sodium Laurel Sulfate is negative) resulting in negating the desired effect.
