Why not just use cell culture or fermentation?
Because transgenic production provides natural biological efficiency and resulting favorable production economics. The mammary gland is an ideal bioreactor for producing recombinant proteins. It has a cell density up to 1,000 times greater than a mammalian cell culture bioreactor, and it can achieve sustainable protein yields of 10 or more grams of recombinant protein per liter of milk per day. Protein production is continuous throughout the lactation cycle, which lasts up to ten months in each animal. Although goats are seasonal breeders, appropriate animal care and breeding methods enable uninterrupted year-round milk production. 7. How well do transgenic animals glycosylate proteins? The mammary gland is designed to produce glycoproteins to nourish suckling newborns. Recombinant proteins expressed in the milk of transgenic animals have mammalian patterns of glycosylation. These glycosylation patterns may differ slightly from native human proteins. Nonetheless, a large number of diff
