Why monitor platelet function?
Platelets play an integral role in coagulation. They are involved in and affected by the inflammatory response, and there is a growing appreciation that manipulation of platelet function can modify and possibly prevent the sequelae of diseases associated with arteriolar thrombosis and occlusion. Excessive platelet aggregation is associated with thrombosis and tissue ischaemia (myocardial infarction/ stroke). Excessive platelet inhibition is associated with haemorrhage. In the context of extra-corporeal circulation, platelet function can be adversely affected, compounding coagulopathy and risk of bleeding. Indiscriminate transfusion of blood and blood products, including platelets, is dangerous. A sensitive and specific test of platelet function will have far reaching implications; on the one hand it will enable clinicians to assess the adequacy of antiplatelet therapy and guide further therapy. On the other hand, accurate assessment of platelet contribution to haemostasis in situations
