Why measure GFR as an index of kidney function?
GFR is usually accepted as the best overall index of kidney function in health and disease. Normal GFR varies according to age, sex, and body size; in young adults it is approximately 120-130 mL/min/1.73 m2 and declines with age. A decrease in GFR precedes the onset of kidney failure; therefore a persistently reduced GFR is a specific diagnostic criterion for CKD. Below60 mL/min/1.73 m2, the prevalence of complications of CKD increases, as does the risk of cardiovascular disease.
