Why is understanding genetic risk important for breast cancer?
The deCODE BreastCancer™ test provides new information on the genetic risk contribution of 7 highly significant DNA variants, risk information that seems in general to be an addition to the currently used risk-assessment tools, but is not a replacement. It seems to be specifically important for the group of women who will be moved up or down in risk category by multiplication of their basic or modeled risk with the deCODE BreastCancer TM results. The deCODE BreastCancer™ test makes a significant contribution to modifying basic or modeled risks since it is to a great extent independent of the individual factors currently used in attempts to estimate future breast cancer risk in individuals. Validations of the significance and magnitude of association for each of the 7 SNPs evaluated in the deCODE BreastCancer™ test are based on studies of 4,500 to 26,000 breast cancer cases and between 17,500 and 32,000 controls. deCODE and others have shown that the markers used are independent of imme
