Why is this a better way of detecting endometrial defects than histological dating (presence of the glycogen vacuole)?
See handout and slide show. Cyclin E drives cells to the S phase of the cell cycle. It is inhibited by p27. Cyclin E is therefore expressed most abundantly in the proliferative phase. It should not be expressed in the secretory phase. If it is found on day 24, for example, this indicates that the endometrium is immaturenot fully developed and able to support a pregnancy. Often patients present with a normal histological appearance (normal droplet of glycogen in the cytoplasm), but they have an abnormal expression of cyclin E. Thus, the normal histology is not detecting the underlying abnormality in the glands (their lack of maturity). This is called glandular developmental arrest. 3. Understand the value and use of basal body temperature for predicting fertility. The BBT is low and goes down slightly just before ovulation. Then, it rises 0.5-0.6 degrees and remains high as long as the corpus luteum is alive. Thus, it predicts ovulation and the life of the corpus luteum, which should be
