Why is there both hypertension and hypotension under toxicity with ganglionic stimulants?
Persistent ganglionic stimulation can cause a depolarizing block much like the action of succinylcholine. The initial increased ganglionic stimulation (ie. nicotine) leads to an increased sympathetic stimulation to the vascular smooth muscle (amoung other actions) leading to vasconstriction via alpha1-receptors (hypertension). However if the nicotine stimulation is excessive then it begins to act like succinylcholine, resulting in a depolarizing blockade in the ganglia (ie. it resembles the actions of a ganglionic blocker). This then causes the BP to fall (hypotension).
Related Questions
- What about blood pressure fluctuation after dosing with Dexmedetomidine in patients with pre-surgical hypertension / hypotension?
- Could you explain why toxicity of acetylcholinesterase inhibitors includes both Hypotension and hypertension?
- Why is there both hypertension and hypotension under toxicity with ganglionic stimulants?
