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Why is there a slow decrease of OD340 WIth time even in the medium control?

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Why is there a slow decrease of OD340 WIth time even in the medium control?

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Fetal Calf Serum used in the medium is a (usually small) source of LDH activity. If this activity is too high, you may try to reduce the amount of FCS in your medium or switch to another FCS source.

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