Why is the TDIinh reccommended for toluene much larger than it was previously?
The new recommended inhalation TDI of 1,400 µg kg 1 bw day 1 is much larger than the old value of 74 µg kg 1 bw day 1 recommended in the 2004 report. This is due to the recent availability of more extensive occupational data which provide a greater level of insight and understanding of the dose–response of inhaled toluene in humans. Consequently, the uncertainty in the assessment and the uncertainty factors required to have confidence that the derived HCV is tolerable to the wider human population are reduced and the HCV is increased.
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- Why is the TDIinh reccommended for toluene much larger than it was previously?
