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Why is the relative proportion of 1-84 PTH (or CAP ) and its inhibitor 7-84 PTH (or CIP ) important?

April 26, 2017cap CIP inhibitor proportion Pth relative

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Why is the relative proportion of 1-84 PTH (or CAP ) and its inhibitor 7-84 PTH (or CIP ) important?

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If CAP (1-84 PTH) is proportionately much greater than CIP (7-84 PTH), then the patient is in a high bone turnover state. If CIP (7-84 PTH) is greater proportionally than CAP (1-84 PTH), (i.e., the CAP /CIP ratio is less than one), then the untreated renal dialysis patient is in an adynamic low bone turnover state. (Ref. Monier-Faugere, Malluche, et. al., Kidney International, 2001; 60:1460-1468.) Bone biopsy studies have demonstrated that the CAP /CIP ratio is highly predictive of renal bone status (predictability is 93%). (Ref. Monier-Faugere, Malluche, et. al., Kidney International, 2001; 60:1460-1468.

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If CAP (1-84 PTH) is proportionately much greater than CIP (7-84 PTH), then the patient is in a high bone turnover state. If CIP (7-84 PTH) is greater proportionally than CAP (1-84 PTH), (i.e., the CAP /CIP ratio is less than one), then the untreated renal dialysis patient is in an adynamic low bone turnover state. (Ref. Monier-Faugere, Malluche, et. al., Kidney International, 2001; 60:1460-1468.) Bone biopsy studies have demonstrated that the CAP /CIP ratio is highly predictive of renal bone status (predictability is 93%). (Ref. Monier-Faugere, Malluche, et.