Why is the database called “Predicted and Consensus Interaction Sites in Enzymes”?
We already described the consensus interactions sites, extracted from the relevant structures in the PDB. Since for a large fraction of enzymes no or limited interaction data are available, future releases of the database will also include interactions predicted by solvent mapping, a novel method for determining protein binding sites based on their structure. For reference see Silberstein, M., Dennis, S., Brown, L., Kortvelyesi, T., Clodfelter, K. and Vajda, S. (2003) Identification of substrate binding sites in enzymes by computational solvent mapping. J. Mol Biol. 332, 1095-1113.
